“A Horizon 2020 MSCA-RISE experience - Innovation in health, from ideas to applications: a system approach to design customized functional tissue analogues” will take place June 6, 2019 in Caserta, Italy. The aim of this workshop is to present the results obtained in the framework of the Second. R.I. project, bringing together the most relevant representatives of the European biomaterials S&T community, and also exploring future directions and possible options on how to systematically streamline collaborative breakthrough research into a dynamic innovation ecosystem.